Description
SN38 is the active metabolite of the chemotherapy drug irinotecan (Camptosar). It is a topoisomerase I inhibitor, prevents the enzyme from properly resealing the DNA strands after they have been unwound, which leads to the accumulation of DNA damage.
Specifications
|
Cat.No. |
31905ES60/31905ES80 |
|
Size |
100 μg/1 mg |
|
Source |
Monoclonal anti-SN38 antibody, is produced from a hybridoma which was obtained from a mouse immunized with SN38. |
|
Buffer |
1×PBS, pH7.4. |
|
Type |
Monoclonal Antibody |
|
Isotype |
IgG1 |
|
Host |
Mouse |
|
Concentration |
1 mg/mL |
|
Purity |
＞95% as determined by reduced SDS-PAGE ＞99% as determined by non-reduced SDS-PAGE > 99% as determined by SEC-HPLC |
|
Activity |
EC50=80.5 ng/mL by ELISA |
|
Application |
ELISA |
Storage
This product should be stored at -25~-15℃ for one year, do not freeze.
Notes
- This product is for research use only.
- Please operate with lab coats and disposable gloves, for your safety.
Data
SDS-PAGE
Anti-SN-38 mouse mAb on SDS-PAGE under reduced condition. The purity is 95.5%；
Anti-SN-38 mouse mAb on SDS-PAGE under non-reduced condition. The purity is 99.2%.
SEC-HPLC
The purity of Anti-SN-38 mouse mAb is 100% as determined by SEC-HPLC.
ELISA Data
Dose response curve shows that the EC50 of Anti-SN-38 mouse mAb is 80.5 ng/mL.