Description
MMAE, or monomethyl auristatin E, is a potent cytotoxic agent commonly used in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It is an antimitotic agent which inhibits cell division by blocking the polymerization of tubulin.
Specifications
|
Cat.No. |
31903ES60/31903ES80 |
|
Size |
100 μg/1 mg |
|
Source |
Monoclonal anti-MMAE antibody, is produced from a hybridoma which was obtained from a mouse immunized with MMAE. |
|
Buffer |
1×PBS, pH7.4. |
|
Type |
Monoclonal Antibody |
|
Isotype |
IgG1 |
|
Host |
Mouse |
|
Concentration |
1 mg/mL |
|
Purity |
＞94% as determined by reduced SDS-PAGE ＞97% as determined by non-reduced SDS-PAGE > 98% as determined by SEC-HPLC |
|
Activity |
EC50=6.3 ng/mL by ELISA |
|
Application |
ELISA |
Storage
This product should be stored at -25~-15℃ for one year, do not freeze.
Notes
- This product is for research use only.
- Please operate with lab coats and disposable gloves, for your safety.
Data
SDS-PAGE
Anti-MMAE mouse mAb on SDS-PAGE under reduced condition. The purity is 94.7%；
Anti-MMAE mouse mAb on SDS-PAGE under non-reduced condition. The purity is 97.6%.
SEC-HPLC
The purity of Anti-MMAE mouse mAb is 98% as determined by SEC-HPLC.
ELISA Data
Dose response curve shows that the EC50 of Anti-MMAE mouse mAb is 6.3 ng/mL.