Description
Exatecan（DXD）is a synthetic derivative of the naturally occurring compound camptothecin. it binds to the topoisomerase 1-DNA complex, preventing DNA re-ligation which results in the accumulation of DNA strand breaks and ultimately leads to cell death.
Specifications
|
Cat.No. |
31902ES60/31902ES80 |
|
Size |
100 μg/1 mg |
|
Source |
Monoclonal anti-DXD antibody, is produced from a hybridoma which was obtained from a mouse immunized with DXD. |
|
Buffer |
1×PBS, pH7.4. |
|
Type |
Monoclonal Antibody |
|
Isotype |
IgG1 |
|
Host |
Mouse |
|
Concentration |
1 mg/mL |
|
Purity |
＞98% as determined by reduced SDS-PAGE ＞98% as determined by non-reduced SDS-PAGE > 98% as determined by SEC-HPLC |
|
Activity |
EC50=41.4 ng/mL by ELISA |
|
Application |
ELISA |
Storage
This product should be stored at -25~-15℃ for one year, do not freeze.
Notes
- This product is for research use only.
- Please operate with lab coats and disposable gloves, for your safety.
Data
SDS-PAGE
Anti-DXD mouse mAb on SDS-PAGE under reduced condition. The purity is 98.2%；
Anti-DXD mouse mAb on SDS-PAGE under non-reduced condition. The purity is 98.4%.
SEC-HPLC
The purity of Anti-DXD mouse mAb is 99% as determined by SEC-HPLC.
ELISA Data
Dose response curve shows that the EC50 of Anti-DXD mouse mAb is 41.4 ng/mL.