Description
DM1, also known as maytansine, is a microtubulin inhibitor, potentially conjugated with monoclonal antibodies to form antibody-drug conjugates(ADCs). DM1 as the toxin component of ADCs, exhibits strong anti-tumor activity by inhibiting cell division and inducing apoptosis.
Specifications
|
Cat.No. |
31901ES60/31901ES80 |
|
Size |
100 μg/1 mg |
|
Source |
Monoclonal anti-DM1 antibody, is produced from a hybridoma which was obtained from a mouse immunized with DM-1. |
|
Buffer |
1×PBS, pH7.4. |
|
Type |
Monoclonal Antibody |
|
Isotype |
IgG1 |
|
Host |
Mouse |
|
Concentration |
1 mg/mL |
|
Purity |
＞94% as determined by reduced SDS-PAGE ＞97% as determined by non-reduced SDS-PAGE > 98% as determined by SEC-HPLC |
|
Activity |
EC50=8.6 ng/mL by ELISA |
|
Application |
ELISA |
Storage
This product should be stored at -25~-15℃ for one year, do not freeze.
Notes
- This product is for research use only.
- Please operate with lab coats and disposable gloves, for your safety.
Data
SDS-PAGE
Anti-DM1 mouse mAb on SDS-PAGE under reduced condition. The purity is 93.4%；
Anti-DM1 mouse mAb on SDS-PAGE under non-reduced condition. The purity is 98.0%.
SEC-HPLC
The purity of Anti-DM1 mouse mAb is 96.8% as determined by SEC-HPLC.
ELISA Data
Dose response curve shows that the EC50 of Anti-DM1 mouse mAb is 8.6 ng/mL.