Description
IL-12 is a cytokine protein that plays a key role in the immune system's response to infection and cancer. It stimulates the activation and proliferation of T cells and natural killer cells, and also stimulates the production of interferon-gamma, an important immune signaling molecule. IL-12 has been studied for its potential use in cancer immunotherapy and vaccine development.
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Synonyms |
Interleukin-12,?IL-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF |
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Uniprot No. |
IL-12A:P29459-1£»IL-12B:P29460-1 |
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Source |
Recombinant Human IL-12 Protein?is expressed from HEK293 Cells with His tag at the N-terminal. IL-12A contains Arg23-Ser219. IL-12B contains Ile23-Ser328. |
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Molecular Weight |
The protein has a predicted MW of?24.5?kDa(IL-12A)&36.6kDa(IL-12B). And it migrates as 35-40?kDa(IL-12A)&40-55kDa(IL-12B) under reducing (R) condition (SDS-PAGE) due to glycosylation. |
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Concentration |
1mg/ml. |
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Purity |
> 95% as determined by SDS-PAGE. |
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Endotoxin |
<1 EU per 1¦Ìg of the protein by the LAL method. |
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Formulation |
Supplied as sterile PBS, pH 7.4. |
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The product?should?be stored at -25~-15¡æ?for 1 year from date of receipt.
2-7 days, 2 ~8 ¡ãC under sterile conditions after reconstitution.
3 months, -25~-15¡æ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used?and avoid repeated freeze-thaw cycles.
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1.Please operate with lab coats and disposable gloves,for your?safety.
2.This product is for research use only.